Endocrine Abstracts

Long-acting somatostatin analogs are now increasingly being prescribed as adjuvant and primary therapy for the treatment of acromegaly. Many studies have shown them to be both effective and safe, by suppressing GH levels and normalizing serum IGF-1 levels in most cases.The aim of the study was to analyze the case report of a female patient with active acromegaly and evaluate the efficacy of long-acting synthetic analog of somatostatin (Sandostatin LAR) for biochemical control ...

The current PDA recommendations relating to the good metabolic control of diabetes are: self-controlled fasting blood glucose (FBG)70–90 mg%, HbA1c ≤6.1%, lipid profile (LP) TChol ≤175 mg%, LDL≤100 mg%, HDL ≥40 mg%, TG≤150 mg%.Objective: To evaluate the accomplishment of the proper metabolic control in diabetic outpatients with regard to the PDA guidelines.Material and Methods: a548 diabetics (249...

Introduction: Insulinomas are usually singular adenomas <1 cm. Less than 5% have diameter >3 cm. Multiple adenomas frequency is estimated on 3 do 9%. Malignant insulinomas are diagnosed in 3–6% patients. The oldest patient with insulinoma described in literature was 95 years old. About 30–50% of patients are previously misdiagnosed.Aim of the study: The aim of the study was presentation of patients with rare clinical characteristics of ...

Introduction: Hypopituitary patients receiving conventional hormone substitution, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.Aim of the study: The aim ...

Objective: The aim of the study was to evaluate distribution of circulating adiponectin (AdipoQ) isoforms at pregnant women with gestational diabetes mellitus (GDM) and comparison analysis of isoform distribution changes 12 months after delivery.Design: The study was conducted on 64 pregnant women who underwent routine pre-natal tests for GDM between 24 and 28 week of gestation and 30 of them 12 months after delivery. The study group included 36 women di...

Introduction: Hypopituitary patients receiving conventional hormone replacement, but without GH replacement, have an increased mortality from cardiovascular diseases. Inadequate hormone replacement is a possible cause of this increased mortality. GH deficiency in adult patients has been associated with several cardiovascular risk factors, including hyperlipidemia, increased abdominal adiposity, and impaired insulin sensitivity.The aim of the study is an ...

The silent myocardial ischemia is a serious diagnostic problem especially in patients with long-standing diabetes of type 1 (DM). Resting as well as exercise myocardial perfusion scintigraphy tests allow to recognize the silent myocardial ischemia in these groups of patients and to start the relevant treatment. The aim of the study was to establish the prevalence of myocardial ischemia in patients with type 1 DM, without clinical symptoms of ischemic heart disease (IHD) and wi...

Introduction: Adiponectin (AdipoQ) is a known insulinsensitizing adipokine which is also present in fetal circulation. It has been postulated to play a role in the regulation of fetal growth and development together with other adipokines. The aim of the study was to determine fetal adiponectin and find its correlations with the neonatal birthweight and maternal AdipoQ.Patients and methods: The study included 36 women with singleton pregnancy (20 diagnose...

Introduction: The course of type 2 diabetes (DM2) is linked with increased fibroblast growth factor 21 (FGF21) concentrations, however little information is available on the prognostic significance of FGF21 in DM2. The aim of the study was to assess whether FGF21 may be a predictor of cardiovascular (CV) events in patients with DM2.Patients and methods: The study comprised 87 patients with DM2, aged 57–66 years, with the median duration of diabetes ...

Background and aims: The subclinical inflammation connected with hypoadiponectinaemia and inflammatory pattern may favor the development of gestational diabetes mellitus (GDM).Methods: In total, 66 pregnant women were enrolled in the study during systematic testing for GDM between 24 and 28 weeks of gestation. GDM was diagnosed in 42 cases, 24 were normal glucose tolerant control group (NGT). In blood serum concentration of glucose, insulin, adiponectin ...